98hydrogel有效期

㈠ 胡先明的近期发表部分论文

2009年1.Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruimin Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu*, Synthesis and potential anticonvulsant activity of new N-3-substituted 5, 5-cyclopropane spirohydantoins, European Journal of Medicinal Chemistry, 2009, 44, 296-302.2.Xiao Ju Zhoua, Yi Mu Yib, Jing Wanb, Xian Ming Hua,* Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles, Drug Development and Instrial Pharmacy, 2009 , 35(3), 305 – 310.3.Xiao Ju Zhou, Yan Hu, Yanping Tian, Xian Ming Hu*, Effect of N-trimethyl chitosan enhancing the dissolution properties of the lipophilic drug cyclosporin A, Carbohydrate Polymers, 2009, 76（2），285-290.4.Xianbing Ke, Hao Hu, Keda Zhang, Wenjin Xu, Qifeng Zhu, Lamei Wu, and Xianming Hu*, Significant Steroids: Effective and General Synthesis of 4α- and 4β-Amino-5α-Androstanes, Chemical Communications，2009，1037-1039.5.Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu*, Novel Biodegradable Hydrogels based on Pachyman and its Derivatives for Drug Delivery, International Journal of Pharmaceutics, 2009, 371, 89–98.6.Xianbing Ke, Hao Hu, Dingshan Zhou, Wenjin Xu, Qifeng Zhu, N. Pulla Reddy, Xianming Hu*, A Facile and General Synthesis of 2β-Aminosteroids, Synthesis, 2009, 8, 1255-1260. 7.Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu*, The Influence of Substituents on the Hydroxyl-Bearing Carbon in the Aza-Payne Rearrangement of Aziridinemethanols, Letters in Organic Chemistry, 2009, 6, 412-415.8.Yuling Xiao, Qifeng Zhu, Wenjin Xu, Lamei Wu, Shucai Liang, Xianming Hu*. Preparation and characterization of a novel pachyman-based pharmaceutical aid II. A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs, Carbohydrate Polymers, (2009) , 77(3), 612-620. 9.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu,*.Asymmetric rection of acetophenone using a,a-disubstituted aziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical，(2009), 300(1-2), 25-28.
2010年1.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Hao Guo, Hao Hu, Dingshan Zhou and Xianming Hu,Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides, European Journal of Medicinal Chemistry, 2010, 45(9): 3636-3644.2.Xianran He, Guanpeng Qiu, Jin Yang, Yuling Xiao, Zhongyuan Wu, Guofu Qiu, Xianming Hu. Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4, 6-diazaspiro[2.4]heptane-5, 7-diones. European Journal of Medicinal Chemistry, 2010, 45(9): 3818-3830.3.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Yinya Xu, Wenhong Huang, Ping Long, Ruimin Li and Xianming Hu. Synthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A. The Journal of Antibiotics, 2010, 63(7):343-350.4.Jin Yang, Yuling Xiao, Xianran He, Zhongyuan Wu, Guofu Qiu, Xianming, Hu, Aesculetin-inced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J. Asian Nat. Prod. Res., 2010, 12(3): 185– 193.5.Xianran He, Min Zhong, Tao Zhang, Wen Wu, Yuling Xiao, Jin Yang, Zhongyuan Wu, Yuanhu Pan, Guofu Qiu, Xianming Hu*. Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. European Journal of Medicinal Chemistry, 45 (2010) 5870-5877

㈡ 张志凌的武汉大学化学与分子科学学院导师

1997年7月于吉林大学化学系获学士学位，
2002年11月于武汉大学化学与分子科学学院获博士学位。
2001年7月作为优秀人才提前留校工作，
2003年10月赴法国巴黎高等师范学校（ENS）进行一年的博士后工作，
2005年晋升副教授，
2008年破格晋升教授。
目前主要从事微流控芯片，生物电分析和纳米生物医学传感等方面的研究。湖北省仪器仪表协会常务理事。国家基金委“新型生物医学探针技术基础及应用”创新研究群体及教育部“化学生物学应用基础研究”创新团队骨干成员。
2006年获教育部高等学校科学技术奖自然科学奖一等奖（第2完成人）。发表论文SCI论文60余篇。申请国家发明专利15项（已授权8项）。湖北省及国家精品课程（武汉大学《分析化学》）主讲教师之一。 1. 国家自然科学基金面上项目（20875072）“集成化细胞分析微流控芯片研制”
2. 国家自然科学基金青年基金（20305011）“DNA与蛋白质相互作用的表面分析化学研究”
3. 国家科技部863专题课题（2006AA03Z320）“高灵敏快速诊断用荧光-磁性-生物靶向三功能纳米球的研发”
4. 教育部留学回国人员科研启动基金（教外司留[2005]383号）“微流控芯片通道表面生物功能化及生化分析中的应用” 1. 国家自然科学基金创新研究群体项目（20621502）“新型生物医学探针技术基础及应用”
2. 国家科技部973项目“微流控学在化学和生物医学中的应用基础研究”子课题（2007CB714507） “传染性疾病诊断微流控新方法及其应用研究”
3. 国家科技部国家重大科学研究计划项目（s973）“病毒与细胞相互作用的荧光纳米实时检测新技术及动态过程可视化”课题（2006CB933101）“基于荧光纳米材料标记的病原体检测新技术”
4. 国家自然科学基金重大项目“微流控生物化学分析系统的基础研究”子课题（20299034）“微流控系统中的细胞操纵及其生化组分分析方法研究”
5. 国家科技攻关计划“生物纳米与医药”国家纳米科技重大专项课题（2003BA310A22）“新型纳米生物医用材料－多功能量子点的研发”（副组长）
6. 教育部创新团队发展计划（教技函[2006]8号IRT0543）“化学生物学应用基础” 1. Zhi-Ling Zhang, Dai-Wen Pang*, Rong-Ying Zhang, Jia-Wei Yan, Bing-Wei Mao, Yi-Peng Qi. Investigation of DNA Orientation on Gold by EC-STM. Bioconjugate Chem. 13(1) (2002)104-109. (影响因子3.766)
2. Zhi-Ling Zhang, C. Crozatier, M. Le Berre, Yong Chen, In-Situ Bio-functionalization and Cell Adhesion in Microfluidic Devices. Micro and Nano Engineering International Conference (2004) 40-41.
3. Zhi-Ling Zhang, Dai-Wen Pang*, Hong Yuan, Ru-Xiu Cai, Héctor D. Abruña. Electrochemical DNA Sensing Based on Gold Nanoparticle Amplification. Analytical and Bioanalytical Chemistry 381 (2005) 833–838. (影响因子2.098)
4. Yuan-Hai Zhu, Zhi-Ling Zhang*, Dai-Wen Pang, Electrochemical oxidation of theophylline at multi-wall carbon nanotube modified glassy carbon electrode. J. Electroanal. Chem. 581 (2005) 303-309. (影响因子2.228，通讯作者)
5. Zhi-Ling Zhang, C. Crozatier, M. Le Berre, Yong Chen, In-Situ Bio-functionalization and Cell Adhesion in Microfluidic Devices. Microelectronic Engineering 78-79 (2005) 556-562.
6. Rong-Ying Zhang, Dai-Wen Pang*, Zhi-Ling Zhang, Jia-Wei Yan, Jian-Lin Yao, Zhong-QunTian, Bing-Wei Mao, Shi-Gang Sun. Investigation of Ordered ds-DNA Monolayers on Gold Electrodes. J. Phys. Chem. B, 106(43)(2002)11233-11239. (影响因子3.843)
7. Ye-Fu Wang, Dai-Wen Pang*, Zhi-Ling Zhang, Hu-Zhi Zheng, Jun-Ping Cao, Jun-Tao Shen. Visual Gene Diagnosis of HBV and HCV Based on Nanoparticle Probe Amplification and Silver Staining Enhancement. Journal of Medical Virology, 70(2)(2003)205-211.
8. Zhe-Xue Lu, Lei Zhou, Zhi-Ling Zhang, Wan-Liang Shi, Zhi-Xiong Xie, Hai-Yan Xie, Dai-Wen Pang*, Ping Shen. Cell damage inced by photocatalysis of TiO2 thin films. Langmuir, 19(21)(2003)8765-8768. (影响因子3.295)
9. Hui-Hong Liu, Zhi-Quan Tian, Zhe-Xue Lu, Zhi-Ling Zhang, Min Zhang, Dai-Wen Pang*. Direct Electrochemistry and Electrocatalysis of Heme-proteins Entrapped in Agarose Hydrogel Films. Biosensors & Bioelectronics, 20(2)(2004)294-304. (影响因子3.251)
10. Jing-Xue Shi, Xian-En Zhang, Wei-Hong Xie, Ya-Feng Zhou, Zhi-Ping Zhang, Jiao-Yu Deng, Anthony E. G. Cass, Zhi-Ling Zhang, Dai-Wen Pang, Cheng-Gang Zhang. Improvement of Homogeneity of Analytical Biodevices by Gene Manipulation. Anal. Chem. 76 (3) (2004) 632-638. (影响因子5.450)
11. Guo-Ping Wang, Er-Qun Song, Hai-Yan Xie, Zhi-Ling Zhang, Zhi-Quan Tian, Chao Zuo, Dai-Wen Pang*, Dao-Cheng Wu and Yun-Bo Shi. Biofunctionalization of fluorescent-magnetic-bifunctional nanospheres and their applications. Chem. Commun. (34) (2005) 4276-4278. (影响因子3.997)
12. Min Xie, Hui-Hui Liu, Ping Chen, Zhi-Ling Zhang, Xiao-Hui Wang, Zhi-Xiong Xie, Yu-Min Du, Bo-Qun Pan, Dai-Wen Pang*. CdSe/ZnS-labeled carboxymethyl chitosan as a bioprobe for live cell imaging. Chem. Commun.(2005) 5518-5520. (影响因子3.997)
13. Sheng-Fu Wang,Ting Chen, Zhi-Ling Zhang, Xin-Cheng Shen, Zhe-Xue Lu, Dai-Wen Pang*, Kwok-Yin Wong. Direct Electrochemistry and Electrocatalysis of Heme Proteins Entrapped in Agarose Hydrogel Films in Room-Temperature Ionic Liquids. Langmuir 21(2005) 9260-9266. (影响因子3.295)
14. Hai-Yan Xie, Jian-Gong Liang, Yi Liu, Zhi-Ling Zhang, Dai-Wen Pang*, Zhi-Ke He, Zhe-Xue Lu, Wei-Hua Huang. Preparation and Characterization of Overcoated II-VI Quantum Dots. Journal of Nanoscience and Nanotechnology, 5(6) (2005) 880-886.
15. Hai-Yan Xie, Chao Zuo, Yi Liu, Zhi-Ling Zhang, Dai-Wen Pang*, Xiao-Lan Li, Jian-Ping Gong, Calum Dickinson, Wuzong Zhou, Cell-targeting Multifunctional Nanospheres with both Fluorescence and Magnetism. Small, 1 (2005) 506-509.
16. Hu-Zhi Zheng, Hui-Hui Liu, Shao-Xing Chen, Zhe-Xue Lu, Zhi-Ling Zhang, Dai-Wen Pang*, Zhi-Xiong Xie*, Ping Shen. Yeast transformation process studied by fluorescence labeling technique. Bioconjugate Chem. 16(2) (2005) 250-254.(影响因子3.766)
17. Zhe-Xue Lu, Zhi-Ling Zhang, Ming-Xi Zhang, Hai-Yan Xie, Zhi-Quan Tian, Ping Chen, Hua Huang, Dai-Wen Pang*. Core/shell Quantum Dots-photosensitized Nano-TiO2 Films: Fabrication and Application to the Damage of Cells and DNA. J. Phys. Chem. B, 109 (2005) 22663-22666.
18. 张志凌，左超，庞代文，DNA与金属锇配合物相互作用的表面电化学研究，化学学报，60（22）（2005）2069-2076
已申请专利：
1. 庞代文, 王业富，张志凌，曹军平，蔡汝秀, 郑鹄志. 发明专利: 纳米微粒标记基因探针及其制备方法和应用. 专利号: ZL 01 1 33527.0, 证书号: 第154129 号, 专利申请日: 2001.9.30., 授权公告日: 2004.5.5.
2. 庞代文, 谢海燕, 刘毅, 左超, 张志凌. 发明专利: 荧光磁性多功能纳米材料的制备. 申请号: 200310111290.9, 申请日期: 2003.10.29.
3. 庞代文, 刘毅, 张志凌. 发明专利: 一种油溶性量子点水溶性化的方法. 申请号: 00410013332.x, 申请日期: 2004.6.22.
4. 庞代文, 鲁哲学, 张志凌. 发明专利: 量子点纳米二氧化钛复合膜的制备方法.申请号: 200510018188.3, 申请日期: 2005.1.24.
5. 庞代文, 谢敏, 张志凌, 杜予民. 发明专利: 一种糖生物功能化的水溶性量子点的制备方法-两相超声法. 申请号: 200510018234.X, 申请日期: 2005.2.1.
6. 庞代文, 谢敏, 张志凌, 杜予民. 发明专利: 一种糖生物功能化的水溶性量子点的制备方法-研磨法. 申请号: 200510018233.5, 申请日期: 2005.2.1.
7. 庞代文, 谢海燕, 王国平，张志凌, 宋尔群，石运伯. 发明专利: 三功能纳米球. 申请号: 200510079227.0, 申请日期: 2005.5.23.
8. Dai-Wen Pang，Hai-Yan Xie，Guo-Ping，Wang，Zhi-Ling Zhang，Er-Qun Song，Yun-Bo Shi. Tri-functional nanospheres. US Patent, Application No. 11/335,380, Application date: May 24, 2005.

㈢ 纤维素水凝胶在水中变成乳白色的絮状是为什么有做过的吗

那就是凝胶了！达到了纤维素的凝胶温度就会这样，粘度没有了！出现大量的白色絮状物

㈣ 如何制造医用水凝胶

医用水凝胶有很多种类。总体来说是以去离子水加上一些高分子共聚物和交联剂等物质组成凝胶状。
如一种水凝胶以丙烯酰胺、丙烯酸羟基酯或甲基丙烯酸羟基酯及交联剂的共聚物与去离子纯水组成，共聚物的重量百分比为2-10％，去离子纯水的重量百分比为90-98％。
具体配方不公开的。

㈤ 聚丙烯酰胺水凝胶是什么

聚丙烯酰胺水凝胶就是我们常说的奥美定，经国家药监局审批，在我国医疗整形美容界，被作为长期植入人体的软组织填充材料，用于注射隆胸、丰颞(太阳穴部位)、隆颊、隆臀等美容术。但是在2006年被禁止，注射了聚丙烯酰胺水凝胶的人都要及时取出来才会安全。聚丙烯酰胺水凝胶是一种化学合成物，构成它的单体有剧毒，而化合物无毒性，但注入到人体内后，可能会分解，产生剧毒。由于能在人体内分解成剧毒单体分子，毒害神经系统，损伤肾脏，对生命循环系统造成伤害，世界卫生组织已将这种物质列为可疑致癌物之一，是定时危险炸弹。聚丙烯酰胺水凝胶目前最安全的取出方法就是北京清奥中心的内窥镜取奥技术，内窥镜取奥美定都是采取微创切口,全程内窥镜电脑控制系统跟踪,准确的把握注射的层次计量取出注射物的同时不损伤周边的组织。北京清奥中心将奥美定注射物取出率由95%成功升级到98%，并且结合生物补片修复技术，让您健康的拥有迷人的胸部。本文转载自：