98hydrogel有效期

㈠ 胡先明的近期發表部分論文

2009年1.Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruimin Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu*, Synthesis and potential anticonvulsant activity of new N-3-substituted 5, 5-cyclopropane spirohydantoins, European Journal of Medicinal Chemistry, 2009, 44, 296-302.2.Xiao Ju Zhoua, Yi Mu Yib, Jing Wanb, Xian Ming Hua,* Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles, Drug Development and Instrial Pharmacy, 2009 , 35(3), 305 – 310.3.Xiao Ju Zhou, Yan Hu, Yanping Tian, Xian Ming Hu*, Effect of N-trimethyl chitosan enhancing the dissolution properties of the lipophilic drug cyclosporin A, Carbohydrate Polymers, 2009, 76（2），285-290.4.Xianbing Ke, Hao Hu, Keda Zhang, Wenjin Xu, Qifeng Zhu, Lamei Wu, and Xianming Hu*, Significant Steroids: Effective and General Synthesis of 4α- and 4β-Amino-5α-Androstanes, Chemical Communications，2009，1037-1039.5.Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu*, Novel Biodegradable Hydrogels based on Pachyman and its Derivatives for Drug Delivery, International Journal of Pharmaceutics, 2009, 371, 89–98.6.Xianbing Ke, Hao Hu, Dingshan Zhou, Wenjin Xu, Qifeng Zhu, N. Pulla Reddy, Xianming Hu*, A Facile and General Synthesis of 2β-Aminosteroids, Synthesis, 2009, 8, 1255-1260. 7.Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu*, The Influence of Substituents on the Hydroxyl-Bearing Carbon in the Aza-Payne Rearrangement of Aziridinemethanols, Letters in Organic Chemistry, 2009, 6, 412-415.8.Yuling Xiao, Qifeng Zhu, Wenjin Xu, Lamei Wu, Shucai Liang, Xianming Hu*. Preparation and characterization of a novel pachyman-based pharmaceutical aid II. A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs, Carbohydrate Polymers, (2009) , 77(3), 612-620. 9.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu,*.Asymmetric rection of acetophenone using a,a-disubstituted aziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical，(2009), 300(1-2), 25-28.
2010年1.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Hao Guo, Hao Hu, Dingshan Zhou and Xianming Hu,Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides, European Journal of Medicinal Chemistry, 2010, 45(9): 3636-3644.2.Xianran He, Guanpeng Qiu, Jin Yang, Yuling Xiao, Zhongyuan Wu, Guofu Qiu, Xianming Hu. Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4, 6-diazaspiro[2.4]heptane-5, 7-diones. European Journal of Medicinal Chemistry, 2010, 45(9): 3818-3830.3.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Yinya Xu, Wenhong Huang, Ping Long, Ruimin Li and Xianming Hu. Synthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A. The Journal of Antibiotics, 2010, 63(7):343-350.4.Jin Yang, Yuling Xiao, Xianran He, Zhongyuan Wu, Guofu Qiu, Xianming, Hu, Aesculetin-inced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J. Asian Nat. Prod. Res., 2010, 12(3): 185– 193.5.Xianran He, Min Zhong, Tao Zhang, Wen Wu, Yuling Xiao, Jin Yang, Zhongyuan Wu, Yuanhu Pan, Guofu Qiu, Xianming Hu*. Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. European Journal of Medicinal Chemistry, 45 (2010) 5870-5877

㈡ 張志凌的武漢大學化學與分子科學學院導師

1997年7月於吉林大學化學系獲學士學位，
2002年11月於武漢大學化學與分子科學學院獲博士學位。
2001年7月作為優秀人才提前留校工作，
2003年10月赴法國巴黎高等師范學校（ENS）進行一年的博士後工作，
2005年晉升副教授，
2008年破格晉升教授。
目前主要從事微流控晶元，生物電分析和納米生物醫學感測等方面的研究。湖北省儀器儀表協會常務理事。國家基金委「新型生物醫學探針技術基礎及應用」創新研究群體及教育部「化學生物學應用基礎研究」創新團隊骨幹成員。
2006年獲教育部高等學校科學技術獎自然科學獎一等獎（第2完成人）。發表論文SCI論文60餘篇。申請國家發明專利15項（已授權8項）。湖北省及國家精品課程（武漢大學《分析化學》）主講教師之一。 1. 國家自然科學基金面上項目（20875072）「集成化細胞分析微流控晶元研製」
2. 國家自然科學基金青年基金（20305011）「DNA與蛋白質相互作用的表面分析化學研究」
3. 國家科技部863專題課題（2006AA03Z320）「高靈敏快速診斷用熒光-磁性-生物靶向三功能納米球的研發」
4. 教育部留學回國人員科研啟動基金（教外司留[2005]383號）「微流控晶元通道表面生物功能化及生化分析中的應用」 1. 國家自然科學基金創新研究群體項目（20621502）「新型生物醫學探針技術基礎及應用」
2. 國家科技部973項目「微流控學在化學和生物醫學中的應用基礎研究」子課題（2007CB714507） 「傳染性疾病診斷微流控新方法及其應用研究」
3. 國家科技部國家重大科學研究計劃項目（s973）「病毒與細胞相互作用的熒光納米實時檢測新技術及動態過程可視化」課題（2006CB933101）「基於熒光納米材料標記的病原體檢測新技術」
4. 國家自然科學基金重大項目「微流控生物化學分析系統的基礎研究」子課題（20299034）「微流控系統中的細胞操縱及其生化組分分析方法研究」
5. 國家科技攻關計劃「生物納米與醫葯」國家納米科技重大專項課題（2003BA310A22）「新型納米生物醫用材料－多功能量子點的研發」（副組長）
6. 教育部創新團隊發展計劃（教技函[2006]8號IRT0543）「化學生物學應用基礎」 1. Zhi-Ling Zhang, Dai-Wen Pang*, Rong-Ying Zhang, Jia-Wei Yan, Bing-Wei Mao, Yi-Peng Qi. Investigation of DNA Orientation on Gold by EC-STM. Bioconjugate Chem. 13(1) (2002)104-109. (影響因子3.766)
2. Zhi-Ling Zhang, C. Crozatier, M. Le Berre, Yong Chen, In-Situ Bio-functionalization and Cell Adhesion in Microfluidic Devices. Micro and Nano Engineering International Conference (2004) 40-41.
3. Zhi-Ling Zhang, Dai-Wen Pang*, Hong Yuan, Ru-Xiu Cai, Héctor D. Abruña. Electrochemical DNA Sensing Based on Gold Nanoparticle Amplification. Analytical and Bioanalytical Chemistry 381 (2005) 833–838. (影響因子2.098)
4. Yuan-Hai Zhu, Zhi-Ling Zhang*, Dai-Wen Pang, Electrochemical oxidation of theophylline at multi-wall carbon nanotube modified glassy carbon electrode. J. Electroanal. Chem. 581 (2005) 303-309. (影響因子2.228，通訊作者)
5. Zhi-Ling Zhang, C. Crozatier, M. Le Berre, Yong Chen, In-Situ Bio-functionalization and Cell Adhesion in Microfluidic Devices. Microelectronic Engineering 78-79 (2005) 556-562.
6. Rong-Ying Zhang, Dai-Wen Pang*, Zhi-Ling Zhang, Jia-Wei Yan, Jian-Lin Yao, Zhong-QunTian, Bing-Wei Mao, Shi-Gang Sun. Investigation of Ordered ds-DNA Monolayers on Gold Electrodes. J. Phys. Chem. B, 106(43)(2002)11233-11239. (影響因子3.843)
7. Ye-Fu Wang, Dai-Wen Pang*, Zhi-Ling Zhang, Hu-Zhi Zheng, Jun-Ping Cao, Jun-Tao Shen. Visual Gene Diagnosis of HBV and HCV Based on Nanoparticle Probe Amplification and Silver Staining Enhancement. Journal of Medical Virology, 70(2)(2003)205-211.
8. Zhe-Xue Lu, Lei Zhou, Zhi-Ling Zhang, Wan-Liang Shi, Zhi-Xiong Xie, Hai-Yan Xie, Dai-Wen Pang*, Ping Shen. Cell damage inced by photocatalysis of TiO2 thin films. Langmuir, 19(21)(2003)8765-8768. (影響因子3.295)
9. Hui-Hong Liu, Zhi-Quan Tian, Zhe-Xue Lu, Zhi-Ling Zhang, Min Zhang, Dai-Wen Pang*. Direct Electrochemistry and Electrocatalysis of Heme-proteins Entrapped in Agarose Hydrogel Films. Biosensors & Bioelectronics, 20(2)(2004)294-304. (影響因子3.251)
10. Jing-Xue Shi, Xian-En Zhang, Wei-Hong Xie, Ya-Feng Zhou, Zhi-Ping Zhang, Jiao-Yu Deng, Anthony E. G. Cass, Zhi-Ling Zhang, Dai-Wen Pang, Cheng-Gang Zhang. Improvement of Homogeneity of Analytical Biodevices by Gene Manipulation. Anal. Chem. 76 (3) (2004) 632-638. (影響因子5.450)
11. Guo-Ping Wang, Er-Qun Song, Hai-Yan Xie, Zhi-Ling Zhang, Zhi-Quan Tian, Chao Zuo, Dai-Wen Pang*, Dao-Cheng Wu and Yun-Bo Shi. Biofunctionalization of fluorescent-magnetic-bifunctional nanospheres and their applications. Chem. Commun. (34) (2005) 4276-4278. (影響因子3.997)
12. Min Xie, Hui-Hui Liu, Ping Chen, Zhi-Ling Zhang, Xiao-Hui Wang, Zhi-Xiong Xie, Yu-Min Du, Bo-Qun Pan, Dai-Wen Pang*. CdSe/ZnS-labeled carboxymethyl chitosan as a bioprobe for live cell imaging. Chem. Commun.(2005) 5518-5520. (影響因子3.997)
13. Sheng-Fu Wang,Ting Chen, Zhi-Ling Zhang, Xin-Cheng Shen, Zhe-Xue Lu, Dai-Wen Pang*, Kwok-Yin Wong. Direct Electrochemistry and Electrocatalysis of Heme Proteins Entrapped in Agarose Hydrogel Films in Room-Temperature Ionic Liquids. Langmuir 21(2005) 9260-9266. (影響因子3.295)
14. Hai-Yan Xie, Jian-Gong Liang, Yi Liu, Zhi-Ling Zhang, Dai-Wen Pang*, Zhi-Ke He, Zhe-Xue Lu, Wei-Hua Huang. Preparation and Characterization of Overcoated II-VI Quantum Dots. Journal of Nanoscience and Nanotechnology, 5(6) (2005) 880-886.
15. Hai-Yan Xie, Chao Zuo, Yi Liu, Zhi-Ling Zhang, Dai-Wen Pang*, Xiao-Lan Li, Jian-Ping Gong, Calum Dickinson, Wuzong Zhou, Cell-targeting Multifunctional Nanospheres with both Fluorescence and Magnetism. Small, 1 (2005) 506-509.
16. Hu-Zhi Zheng, Hui-Hui Liu, Shao-Xing Chen, Zhe-Xue Lu, Zhi-Ling Zhang, Dai-Wen Pang*, Zhi-Xiong Xie*, Ping Shen. Yeast transformation process studied by fluorescence labeling technique. Bioconjugate Chem. 16(2) (2005) 250-254.(影響因子3.766)
17. Zhe-Xue Lu, Zhi-Ling Zhang, Ming-Xi Zhang, Hai-Yan Xie, Zhi-Quan Tian, Ping Chen, Hua Huang, Dai-Wen Pang*. Core/shell Quantum Dots-photosensitized Nano-TiO2 Films: Fabrication and Application to the Damage of Cells and DNA. J. Phys. Chem. B, 109 (2005) 22663-22666.
18. 張志凌，左超，龐代文，DNA與金屬鋨配合物相互作用的表面電化學研究，化學學報，60（22）（2005）2069-2076
已申請專利：
1. 龐代文, 王業富，張志凌，曹軍平，蔡汝秀, 鄭鵠志. 發明專利: 納米微粒標記基因探針及其制備方法和應用. 專利號: ZL 01 1 33527.0, 證書號: 第154129 號, 專利申請日: 2001.9.30., 授權公告日: 2004.5.5.
2. 龐代文, 謝海燕, 劉毅, 左超, 張志凌. 發明專利: 熒光磁性多功能納米材料的制備. 申請號: 200310111290.9, 申請日期: 2003.10.29.
3. 龐代文, 劉毅, 張志凌. 發明專利: 一種油溶性量子點水溶性化的方法. 申請號: 00410013332.x, 申請日期: 2004.6.22.
4. 龐代文, 魯哲學, 張志凌. 發明專利: 量子點納米二氧化鈦復合膜的制備方法.申請號: 200510018188.3, 申請日期: 2005.1.24.
5. 龐代文, 謝敏, 張志凌, 杜予民. 發明專利: 一種糖生物功能化的水溶性量子點的制備方法-兩相超聲法. 申請號: 200510018234.X, 申請日期: 2005.2.1.
6. 龐代文, 謝敏, 張志凌, 杜予民. 發明專利: 一種糖生物功能化的水溶性量子點的制備方法-研磨法. 申請號: 200510018233.5, 申請日期: 2005.2.1.
7. 龐代文, 謝海燕, 王國平，張志凌, 宋爾群，石運伯. 發明專利: 三功能納米球. 申請號: 200510079227.0, 申請日期: 2005.5.23.
8. Dai-Wen Pang，Hai-Yan Xie，Guo-Ping，Wang，Zhi-Ling Zhang，Er-Qun Song，Yun-Bo Shi. Tri-functional nanospheres. US Patent, Application No. 11/335,380, Application date: May 24, 2005.

㈢ 纖維素水凝膠在水中變成乳白色的絮狀是為什麼有做過的嗎

那就是凝膠了！達到了纖維素的凝膠溫度就會這樣，粘度沒有了！出現大量的白色絮狀物

㈣ 如何製造醫用水凝膠

醫用水凝膠有很多種類。總體來說是以去離子水加上一些高分子共聚物和交聯劑等物質組成凝膠狀。
如一種水凝膠以丙烯醯胺、丙烯酸羥基酯或甲基丙烯酸羥基酯及交聯劑的共聚物與去離子純水組成，共聚物的重量百分比為2-10％，去離子純水的重量百分比為90-98％。
具體配方不公開的。

㈤ 聚丙烯醯胺水凝膠是什麼

聚丙烯醯胺水凝膠就是我們常說的奧美定，經國家葯監局審批，在我國醫療整形美容界，被作為長期植入人體的軟組織填充材料，用於注射隆胸、豐顳(太陽穴部位)、隆頰、隆臀等美容術。但是在2006年被禁止，注射了聚丙烯醯胺水凝膠的人都要及時取出來才會安全。聚丙烯醯胺水凝膠是一種化學合成物，構成它的單體有劇毒，而化合物無毒性，但注入到人體內後，可能會分解，產生劇毒。由於能在人體內分解成劇毒單體分子，毒害神經系統，損傷腎臟，對生命循環系統造成傷害，世界衛生組織已將這種物質列為可疑致癌物之一，是定時危險炸彈。聚丙烯醯胺水凝膠目前最安全的取出方法就是北京清奧中心的內窺鏡取奧技術，內窺鏡取奧美定都是採取微創切口,全程內窺鏡電腦控制系統跟蹤,准確的把握注射的層次計量取出注射物的同時不損傷周邊的組織。北京清奧中心將奧美定注射物取出率由95%成功升級到98%，並且結合生物補片修復技術，讓您健康的擁有迷人的胸部。本文轉載自：